The Seahawks will look much different from when the 49ers last played them in Week 13 of the 2021 season when Seattle narrowly defeated the 49ers as the clock round down. The most notable change being that for the first time in a decade, quarterback Russell Wilson no longer leads Seattle's offense. During the offseason, the Seahawks traded Wilson and a 2022 fourth-round draft pick to the Denver Broncos for a 2022 first-round pick, a 2022 second-round pick, a 2022 fifth-round pick, a 2023 first-round pick, a 2023 second-round pick, tight end Noah Fant, defensive lineman Shelby Harris and quarterback Drew Lock.

The Seahawks will look much different from when the 49ers last played them in Week 13 of the 2021 season when Seattle narrowly defeated the 49ers as the clock round down. The most notable change being that for the first time in a decade, quarterback Russell Wilson no longer leads Seattle's offense. During the offseason, the Seahawks traded Wilson and a 2022 fourth-round draft pick to the Denver Broncos for a 2022 first-round pick, a 2022 second-round pick, a 2022 fifth-round pick, a 2023 first-round pick, a 2023 second-round pick, tight end Noah Fant, defensive lineman Shelby Harris and quarterback Drew Lock.